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KMID : 0364820180540020136
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Korean Journal of Microbiology
2018 Volume.54 No. 2 p.136 ~ p.139
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Isolation and characterization of bacilysin against Ralstonia solanacearum from Bacillus subtilis JW-1
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Kim Shin-Duk
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Abstract
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The inhibitory compound (Compound S) against Ralstoniasolanacearum and its conversion product (Compound S’) wereisolated from the culture filtrate of Bacillus subtilis JW-1 using aseries of chromatography procedures. The structures were elucidatedas alanyl-L-β-(2,3-epoxycyclohexyl-4-one)alanine andalanyl-L-β-(2,3-dihydroxycyclohexyl-4-one)alanine, respectivelyon the basis of nuclear magnetic resonance spectral data, including1H, 13C, 1H-1H correlation spectroscopy and heteronuclearmultiple bond correlation spectroscopy. The compound S exhibiteda broad antimicrobial activity against G+, G- bacteria, Saccharomycescerevisiae and Candida albicans. The activity loss of the conversionproduct revealed that the epoxy function was essentialfor activity of Compound S.
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KEYWORD
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Ralstonia solanacearum, antibiotic, bacilysin, bacterial wilt
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